甲磺酸培氟沙星对体外鸡毒支原体的抑菌试验和对鸡毒支原体病的治疗试验

Bacteriostatic Effect of Mesylate Pefloxacin on Mycoplasma gallisepticum and Its Treatment Test for M.gallisepticum Infection

利用甲磺酸培氟沙星水溶性粉剂对鸡毒支原体分别进行体内外的抑菌治疗试验。体外抑菌试验结果表明：该药物能有效地抑制试管中鸡毒支原体的生长繁殖。体内试验结果表明：当饮水中药物浓度达到１００ｍｇ／Ｌ时，能有效地防止由于鸡毒支原体引起的死亡；当饮水中药物浓度达到５０ｍｇ／Ｌ以上时，能明显地减轻以至部分消除鸡毒支原体强毒引起的气囊损伤；和感染不治疗对照组相比，该药物能提高鸡体增重；用甲磺酸培氟沙星治疗，能抑制感染鸡体内的鸡毒支原体，从而使部分鸡体内检测不到鸡毒支原体抗体。

The mesylate pefloxacin was used to inhibit Mycedplasma gallisepticum in vitro and to control mycoplasmosis in vivo.The test results show M.gallisepticum was highly sensitive to mesylate pefloxacin in medium(0 025μg/ml).The other results show the chicken were infected with M.gallisepticum were medicated for 5 days via the drinking water with mesylate pefloxacin or were left as unmedicated controls.Chicks were observed for 21 days.The mortality and air sac lesions were reduced obviously when the drug in drinking water 100mg/L and 50mg/L respectively,it also could maintain weigh gain,and reduce seroconversion in medicated birds compared with controls.