纳洛酮联合醒脑静治疗呼吸衰竭并发肺性脑病的疗效分析

The Analysis of Naloxone Combined Xingnaojing Treatment of Respiratory Failure Patients with Pulmonary Encephalopathy

目的探索纳洛酮联合醒脑静治疗呼吸衰竭并发肺性脑病的临床疗效及应用价值。方法选取新丰县人民医院2009年1月至12月收治的呼吸衰竭并发肺性脑病患者40例,采用随机分组对照方法,其中20例使用常规治疗为对照组,另外20例在对照组基础上使用纳络酮联合醒脑静为观察组,两组均治疗2周。综合分析纳洛酮联合醒脑静治疗急性呼吸衰竭并发肺性脑病的临床疗效,及其引发的相关并发症。结果通过对两组病例的临床疗效进行法分析,观察组有效率达到80%,明显高于对照组的65%(P<0.05),而且观察组改善血氧分压及二氧化碳分压的疗效也明显高于对照组(P<0.01)。结论国内外相关临床研究资料与数据表明,纳络酮联合醒脑静能明显改善肺性脑病的症状体征,提高血氧分压,使二氧化碳分压下降,改善酸碱失衡,疗效较好,大大提高了抢救成功率。

Objective To explore the clinical efficacy and value about Naloxone combined Xingnaojing treatment of respiratory failure patient with pulmonary encephalopathy. Methods Select 40 respiratory failure patients with pulmonary encephalopathy in January 2009 to December 2009 from the people＇s hospital of Xinfeng, a randomized control method, in which 20 patients with conventional treatment for the control group, another 20 patients in the control group based on the use of sodium Combined naloxone and Xingnaojing for the observation group, two groups were treated for 2 weeks. Comprehensive analysis of naloxone combined Xingnaojing acute respiratory failure complicated by pulmonary encephalopathy clinical efficacy, and caused complications. Results Two cases by the clinical efficacy analysis, observation group was 80%, significantly higher than the 65% （P〈0.05）, and the observation group to improve the blood oxygen and carbon dioxide partial pressure of the curative effect control group （P〈0.01）. Conclusion Domestic and foreign research data and clinical data show that： Naloxone with Xingnaojing can significantly improve the signs and symptoms of pulmonary encephalopathy, increased blood partial pressure of oxygen, carbon dioxide partial pressure decreased, improving the acid-base imbalance and effective, which greatly improve the success rate of resuscitation.