单唾液酸四己糖神经节苷脂治疗脑梗塞疗效分析

Effective analysis of treating infarction with GM1

目的：观察单唾液酸四己糖神经节苷脂治疗脑梗塞的临床疗效。方法：选择我院2008年1月至2009年12月住院病人符合纳入标准的脑梗塞患者74例，采用随机分组法，分为治疗组（38例）和对照组（36例），治疗组给予GM140mg，对照组给予脑生素10ml，两组均同时给予血栓通、奥美拉唑、小剂量甘露醇等改善微循环、保护胃黏膜、降颅压，治疗前和治疗2周时进行神经功能缺损程度评定，并进行比较。结果：两组治疗后神经功能缺损程度评分均明显减少，治疗组减少更明显，治疗组与对照组总有效率分别为87．9％（29／33）、51．2％（16／31），差异有统计学意义（P〈0．01）。结论：GM1治疗脑梗塞临床疗效肯定，能减少患者的临床神经功能缺损程度评分，改善患者预后。

Objective： To observe clinical effects of treating infarction with GM1. Methods： From January 2008 to December 2009 choose 74 cases of infarction patient, randomly divied into treatment group （38 cases） and control group （36 cases）, taking GMlfor 40mg in treatment group, taking Naosheng Su 10ml in control group, while taking the Xueshuan Tong, Omeprazole, Low-dose mannitol to improve the microcirculation, protection of gastric mucosa, reducing the intracranial pressure in two groups, before treatment and 2 weeks treatment the degree assessment and compare of neurological deficit. Results： After two treatment groups the degree assessment of neurological deficit was reduce, reduce was more clear in treatment group, the tatol respectively for 87.9% （29/33）, 51.2% （16/31）, difference have statistically means. Conclusion： Clinical effects of treating infarction with GM1, have a good effects, can less the degree assessment of neurological deficit of patient, improve the cure of patient.