健康查体中超重、肥胖者的临床特点及临床意义

Clinical characteristics and significance of overweight or obese people in health examination

目的研究健康查体超重、肥胖者的临床特点及临床意义。方法对解放军总医院工作人员健康查体中的96例超重、肥胖者进行一般状况、血压、血液生化指标及动脉硬化指数检测,应用Cockcroft-Gault公式计算肌酐清除率。另选性别、年龄匹配的99例体重正常的健康查体者作为对照组。结果超重、肥胖组舒张压、肌酐清除率(P<0.01),以及血清三酰甘油浓度(P<0.05)都显著高于对照组;而脉压显著低于对照组(P<0.05)。结论 "健康"的超重、肥胖者存在着舒张压增高、脉压减小、血清三酰甘油水平增高和肾脏高滤过的临床特点,可能预示着心血管疾病和肾脏损害的高风险,应当予以重视。

Objective To investigate the clinical characteristics and significance of overweight or obese people in health examination. Methods All the subjects were among the healthy medical staff in this hospital who underwent annual health examination. There were 96 people in the overweight or obesey group and 99 people in the control group of normal weight. The demographic parameters, blood biochemical parameters and arteriosclerotic index were measured and the ereatinine clearance was calculated according to Cockcroft - Gault equation in all the subjects. All the above parameters were compared between the two groups. Results The values of diastolic blood pressure, creatinine clearance（both P 〈0.01 ） and serum triglyceride（P 〈0.05） were significantly higher in the overweight or obese group than those in the control group while the value of pulse pressure was significantly lower in the overweight or obese group than that in the control group （P 〈 0.05 ）. Conclusions Even healthy overweight or obese people have higher values of diastolic blood pressure, serum triglyceride and creatinine clearance and lower value of pulse pressure than normal-weight healthy people, suggesting that they may have higher risk of cardiovascular diseases and kidney impairment.