硫辛酸类4个代表性化合物稳定性的计算

Calculation of the Chemical Stability of the 4 Typical Derivatives of Lipoic Acid

６，８二硫辛酸的衍生物（Ａ１１０，２２５）作为有效的电辐射防护剂〔１〕，已广泛地应用于军事及和平事业中，其中（２２５）容易形成分子间二硫多聚物，对于制备、质量控制以及实际应用都极为不利〔１〕．５，８二硫辛酸的衍生物（Ａ１１，Ａ１２）不仅化学性质稳...

In order to find stable and new radioprotectors,the ring strains and low energy conformations of 4 typical compounds were obtained through computer aided computing,and by means of molecular mechanics and semiempirical molecular orbital methods respectively.The difference of the stable properties has been explained by the comparison of the ring strains and low energy conformations.The feasibility of compound of A110 and 225 was affirmed.