摘要
目的:评价非络地平缓释片(康宝得维)的临床疗效和安全性。方法:采用随机,单盲,平行对照的方法,用选择性钙离子拮抗剂非络地平缓释片对高血压病进行为期6周的治疗观察,并与另一选择性钙离子拮抗剂苯磺氨氯地平(络活喜)[1]进行对比,共有40例病人完成此项观察研究,其中对照组20例。非络地平缓释片的剂量为5mg~10mg,苯磺氨氯地平为5mg。结果:非络地平缓释片总有效率95.0%,服药6周后平均收缩压(SBP)及舒张压(DBP)分别下降3.19kpa及2.55kpa,苯磺氨氯地平组总有效率90.0%,SBP及DBP的下降幅度为3.45kpa及2.31kpa。两组总有效率无显著差别,不良反应均较少。结论:非络地平缓释片是一种安全有效的抗高血压药物。
OBJECTIVE: To estimate the efficacy and safety of extended release felodipine tablets. METHODS: A comparative study of Extended release felodipine tablets (felo,5-10mg/d)with amlodipine (amlo,5mg/d) was carried out in 40 patients with mild and essential hypertension (EH).Treatment lasted for 6 weeks in a randomized,single blind design RESULTS: Total effective rate was 95.0% in felo group and 90.0% in amlo group.SBP and DBP reductions in felo group were 3.19 kpa and 2.55kpa,and in amlo group 3.45kpa and 2.31kpa.There was no significant difference in total effective rate between the two groups. CONCLUSLON :Extended release felodipine tablets is effective and well tolerated in treating hypertensive patients.
出处
《航空航天医药》
1999年第1期7-8,共2页
Aerospace Medicine
关键词
非络地平
缓释片
高血压
药物疗法
疗效
extended release felodipine tablets,amlodipine,hypertension.