摘要
目的了解2008-2009年中国部分地区脑膜炎奈瑟菌(Nm)分离株的抗生素敏感性变化趋势。方法药敏纸片扩散(K-B)法和E-test试纸条检测方法对本研究室2008-2009年收集的68株分离自患者和健康带菌者菌株进行体外抗菌药物敏感性检测。结果所有菌株对3种治疗药物头孢噻肟、头孢曲松和氯霉素均敏感,1株C群患者菌株对美洛培南耐药,13株对青霉素不敏感菌株,6株对氨苄西林不敏感菌株。6种预防用药组中,除1株Y群带菌者菌株对利福平耐药外,其他菌株对阿奇霉素、米诺环素和利福平均敏感,70.59%菌株对萘啶酸,72.06%对环丙沙星,95.59%对复方新诺明耐药。W135群带菌者菌株对青霉素和氨苄西林敏感株比例较大,2株对磺胺类药物敏感。患者菌株和带菌者菌株药敏谱略有不同。结论磺胺类和喹诺酮类药物仍不被考虑作为流脑的预防性药物,加强对青霉素和氨苄西林治疗药物在各种血清群Nm的耐药性监测。长期对Nm药敏监测非常必要,对流行性脑脊髓膜炎预防和治疗药物的选择应因时因地而宜。
Objective To analyze the antibiotic susceptibility of Neisseria mengitidis （Nm） isolates in some areas in China during 2008-2009.Methods The sensitivity and resistance of 68 strains of Nm isolated from patients and healthy carriers to antibiotics were tested with E-test and Kirby-Bauer method in vitro.Results All strains were sensitive to ceftriaxone,cefotaxime,chloramphenicol.One strain of serogroup C isolated from healthy carrier was resistant to meropenem.Thirteen strains were not sensitive to penicillin and 6 strains were not sensitive to ampicillin.Among 6 strains for prophylactic agents test,all were sensitive to azithromycin,minocycline and rifampicin except one rifampicin resistant strain of serogroup Y,70.59% of strains were resistant to nalidixic acid,72.06% were resistant to ciprofloxacin and 95.59% were resistant to trimethoprim＋sulfamethoxazole.The sensitive rate of strains of W135 serogroup to penicillin and ampicillin was higher than other serogroups strains.Two strains were sensitive to sulfamethoxazole.The pattern of antibiotic sensitivity was different in strains isolated from patients and healthy carrier.ConclusionFluoroquinolones and sulfamethoxazole are not recommended for the prevention of Nm infection.It is necessary to strengthen the surveillance of resistances of all serogroups Nm to penicillin and ampicillin and conduct long term antibiotic sensitivity surveillance to select appropriate antibiotics.
出处
《疾病监测》
CAS
2010年第4期282-285,共4页
Disease Surveillance
