广东省深圳市健康人群肺炎链球菌带菌调查及耐药分析

Carriage and drug susceptibility of Streptococcus pneumoniae among healthy population in Shenzhen

目的了解深圳市健康人群肺炎链球菌(Sp)的带菌状况,分析Sp的耐药性,为制定有效的预防和临床用药方案提供依据。方法将健康人群分为0～、5～、15～、25～和60～岁5个年龄组,采集鼻咽拭子,分离、鉴定Sp,用全自动生化及药敏鉴定分析仪测定Sp的抗生素敏感性。结果深圳市健康人群Sp带菌率为7.7%(40/521),0～、5～、15～、25～和60～岁5个年龄组分别为13.3%、11.7%、5.0%、3.1%、2.4%。所有菌株对盖替沙星、莫西沙星、力奈唑烷、万古霉素、利福平敏感;对青霉素G、复方新诺明、红霉素、四环素耐药性高,分别为52.5%、72.5%、92.5%、95.0%,有多重耐药现象。结论深圳市健康人群鼻咽部Sp携带率为7.7%,Sp菌株对大环内酯类、磺胺类、青霉素类药物耐药情况严重,在临床和预防用药时,应慎重使用。

Objective To learn about the carriage and drug susceptibility of Streptococcus pneumoniae（Sp） among the healthy population in Shenzhen.Methods A total of 521 throat swabs were taken from the healthy people in different age groups in Shenzhen,and Sp was isolated from the throat swabs.The drug susceptibility test was conducted with VITEK 2-Compact.Results Forty strains of Sp were isolated,the overall carriage rate was 7.7%.All 40 strains were sensitive to gatifloxacin,moxifloxacin,linezolid,vancomycin and rifampicin;and were highly resistant to benzylpenicillin,trimethoprim,erythromycin and tetracycline.Conclusion The oral pharyngeal carriage rate of Sp was 7.7% among the healthy population in Shenzhen.The Sp strains showed high resistance to macrolides,sulfanilamide and benzylpenicillin,which should be used cautiously in prophylaxis and therapy.