米索前列醇在人工流产中的应用

Application of misoprostol in artificial abortion

目的:探讨米索前列醇应用于人工流产术的可行性、安全性及有效性。方法:将240例在本院妇产科门诊行人工流产术的患者随机分为口服米索前列醇组(A组,N=80);阴道放置米索前列醇组(B组,N=80)和未使用米索前列醇对照组(C组,N=80)。A组术前2h口服米索前列醇400μg,B组术前阴道放置米索前列醇400μg,C组不使用任何药物。观察并比较两组用药的不良反应,宫颈扩张效果,术中出血量,手术时间及术后宫颈粘连发生情况。结果:B组患者药物不良反应发生率低于A组,两组比较:差异有显著意义(P<0.01)。A、B两组宫颈扩张效果,术中出血量,手术时间及术后宫颈粘连发生率比较:差异无显著意义(P>0.05);但分别于C组比较:差异有极显著意义(P<0.01)。结论:口服和阴道放置米索前列醇均可作为人工流产术前的给药方法,推荐用药后不良反应较小的阴道放置方式。

Objective：To discuss the feasibility,safety and effectiveness of application of misoprostol in artificial abortion.Methods：240 cases of artificial abortion in the outpatient department of gynecology and obstetrics in our hospital were randomly divided into the oral misoprostol group（group A,n=80）,the vaginal putting misoprostol group（group B,n=80） and the non-used misoprostol group（group C,n=80）.Group A took oral misoprostol 400 μg in preoperative 2h;group B used misoprostol 400 μg in vagina before surgery;group C did not use any drugs.To observe and compare the incidence of adverse reactions,effects of cervical dilatation,blood loss,operative time and postoperative incidence of cervical adhesions in group A and group B.Results：The incidence of adverse drug reactions in group B was lower than that in group A.The difference between two groups was significant（P〈0.01）.In group A and group B,the cervical dilatation effects,blood loss,operative time and postoperative incidence of cervical adhesion had no significant difference（P 0.05）,but the difference was significant compared with group C.Conclusion：Oral and vaginal putting misoprostol are the medication methods before artificial abortion operation,but vaginal administration with less adverse reactions is recommeded（P〈0.01）.