盐酸法舒地尔治疗老年人不稳定性心绞痛

Therapeutic effects of fasudil hydrochloride on treating unstable angina pectoris

目的:观察盐酸法舒地尔治疗老年人不稳定性心绞痛(UAP)的疗效。方法:将60例60岁以上老年人UAP患者随机分为治疗组和对照组,每组30例,在常规治疗外,分别采用静脉滴注盐酸法舒地尔30 mg,12小时1次或口服硝苯地平10 mg,3次/日,治疗14天。治疗前后观察两组心绞痛发作情况,并做心电图检查,观察不良反应。治疗后随访6个月。结果:治疗组总有效率83.33%高于对照组73.33%,但两组比较差异无显著性(P>0.05);治疗组显效率(70.00%)高于对照组(40.00%),差异有显著性(P<0.05)。两组均无明显不良反应。随访6个月,对照组死亡1例,死于肺部感染;治疗组发生1例心肌梗死。结论:盐酸法舒地尔可以试用于治疗老年人UAP。

Objective：To observe the therapeutic effects of fasudil hydrochloride on treating unstable angina pectoris（UAP）of aged people.Methods：60 patients,above 60 years old,with UAP were divided into two groups randomly and equally.Beside conventional therapy,the treatment group was treated with fasudil hydrochloride 100 mg once every 12h by intravous drip,for 14 d and the control group was treated with oral nifedipine 10 mg daily,for 14 d.Therapeutic effects were got before and after treatment in both groups through observating angina pectoris attacks and electrocardiogram.At the same time,to observate adverse reactions.Then to follow up for 6 months.Results：The total effective rate（83.33%）of the treatment group was higher than that（73.33%） of the control group without statistical difference（P〈0.05）,but the excellence rate（70.00%） of the treatment group was significantly higher than that（40.00%） of the control group（P〈0.05）.There were no significantly adverse reactions.One patient in treatment group died of myocardial infarction and one patient in control group died of pulmonary infection,but there was no significant difference between two groups（all P〈0.05）.Conclusion： Fasudil hydrochloride could be use to treat UAP of aged people.