复发性流产的免疫治疗效果分析

Effectiveness of Leukocyte Immunotherapy in Recurrent Spontaneous Abortion

目的了解采用淋巴细胞对复发性流产进行主动免疫的疗效。方法采用丈夫外周血淋巴细胞治疗复发性流产,454例患者疗程结束并成功随访,妊娠至20周后者为治愈。结果 116(25.55%)例足月分娩,治愈率70.48%(未包括已孕20周内)。其间1例孕20周诊断无脑儿,1例孕26周超声示胎儿先天性左心发育不良,畸形率0.44%。结论免疫治疗是安全、有效的治疗复发性流产的方法之一,能确实解决病患实际问题。

Objectives：To evaluate the effectiveness of leukocyte immunization therapy for treatment of recurrent spontaneous abortion （RSA）.Methods：454 non-pregnant women recognized as RSA were referred for immunotherapy,all the cases were immunized by isolated lymphocytes from their husbands.Patients up to 20 weeks in gestation were recognized as successfully treatment outcome.116（25.55%）cases out of 454 were given birth,the totally efective rate was 70.48%（not including gestation before 20th week）,we found 1 fetal suffered with anencephaly and 1 congenital heart disease,the malformation rate was 0.44%.Conclusion：The results showed evidence that immunotherapy is one of the effective and safe methods for RSA.