具有血管紧张素Ⅱ受体拮抗活性的异喹啉生物碱及类似物的质谱研究

STUDY ON THE MASS SPECTRUM OF ISOQUINOLINE ALKALOIDS WITH ACTIVITIES OF ANTAGONIST ANGIOTENSIN Ⅱ RECEPTOR

目的：为了寻找具有血管紧张素Ⅱ受体拮抗活性的新类型化合物。方法：我们设计合成了十种新异喹啉生物碱类化合物，在结构鉴定工作中我们对其进行了质谱研究。快原子轰击质谱，电子流轰击质谱。结果：发现了一些新的裂解规律。

Objective:In order to discover the new nonpeptide angiotensin Ⅱ receptor antegonists,ten new isoquinoline alkaloids were syntheized.The structures of these compounds was studied.Methods:FAB MS and EI MS.Results:The mass spectrum cleavage rules of ten isoquinoline alkaloids were found.Conclusion:MS plays an important part in identifying this kind of structure.