摘要
由EBI-3和p28组成的IL-27是IL-12家族的新成员,主要来源于树突状细胞(dendritic cells,DCs)的分泌。当DCs表面的Toll样受体(Toll like receptor,TLR)受到外界信号刺激的时候,通过激活下游因子MyD88、IRF3、c-Rel以及JNK等通路介导IL-27表达。IL-27受体由WSX-1和gp130两个亚基组成,表达于多种免疫细胞和非免疫细胞表面。IL-27对这些细胞的发育、分化和功能都发挥着不可或缺的作用。IL-27与其受体结合后,通过激活下游的STAT1/STAT3途径诱导na?veT细胞向Th1方向分化,同时抑制其向Th2、Th17和Foxp3+Treg方向分化。B细胞抗体类型的转换、DCs表面共刺激分子的表达和促进Th1反应的能力也受到IL-27的调节。另外,IL-27还可以诱导一些非免疫细胞的表面表达MHC分子,使其具有抗原呈递的功能。更具有临床意义的是,IL-27在许多感染性疾病、自身免疫病和肿瘤中都发挥了重要作用,是相关疾病潜在的作用靶点。
IL-27 is a new member of IL-12 family, a heterodimer of EBI-3 and p28, which is mainly secreted by dendritic cells （DCs）. When the Toll-like receptors on the surface of DCs are stimulated, their downstream factor MyD88, IRF3, c-Rel and JNKs are activated and induce IL-27 expression. IL-27 receptor, which is composed by WSX-1 and gp130, is expressed by lots of immunocytes or non-immunocytes. IL-27 plays an important role on the development, differentiation and function of these cells. IL-27 can induce na？ve T cell differentiate to Th1 cells whereas inhibit Th2, Th17 and Foxp3＋ Treg differentiation by activating STAT1/STAT3 pathway. Switch of B cell Ig isoform and DCs co-stimulatory factor expression are also influenced by IL-27. In addition, IL-27 can induce MHC molecules expression on several kinds of non-immunocytes, thus make them get the ability of antigen presentation. In the clinical research, IL-27 plays important roles in plenty kinds of inflammatory diseases, autoimmune diseases and cancers. Therefore, IL-27 may be a new target for the medicines of these diseases.
出处
《生命科学》
CSCD
北大核心
2010年第6期539-545,共7页
Chinese Bulletin of Life Sciences
