摘要
TLR4是天然免疫系统中的一种重要模式识别受体,可选择性识别病原微生物而启动天然免疫,在宿主天然免疫和获得性免疫中具有重要作用。此外,大量研究表明,TLR4基因的多态性与多种动物的细菌、病毒和寄生虫性疾病密切相关,说明通过TLR4基因的研究可为动物分子标记辅助选育研究提供依据。该文简要论述部分动物TLR4基因多态性及其与抗病相关性的研究进展。
TLR4 is an important pattern recognition receptor in the natural immune system, which can activate innate immunity by selectively identifying pathogenic microorganisms and plays an important role in the innate immunity and acquired immunity. According to a lot of researches, the genetic polymorphisms of TLR4 are closely related to a variety of diseases in animals, suggesting that it can provide plenty of information for animal molecular marker-assisted breeding. More information about the polymorphisms of TLR4 gene and their relationships with disease resistance traits in some animals will be introduced briefly in this paper.
出处
《生命科学》
CSCD
北大核心
2010年第6期546-550,共5页
Chinese Bulletin of Life Sciences
基金
现代农业产业技术体系建设专项资金(nycytx-45-02)
浙江省重大科技攻关项目(2005C12005-01)
关键词
TLR4基因
多态性
抗病力
关系
TLR4
polymorphism
disease resistance trait
relationship
