野生与栽培苍术对鼠胃溃疡模型的药理研究

Pharmacological research of wild and cultivated Atractylodes lancea

目的:探讨野生与栽培苍术药材主要药理作用的差异。方法:采用无水乙醇和HC l造模,观察苍术栽培品及野生品70%醇提物对小鼠胃溃疡的影响;采用碳末推进法,观察观察苍术栽培品及野生品70%醇提物对正常小鼠和大黄致脾虚小鼠小肠运动的影响;采用最小抑菌浓度(M IC)测定研究苍术栽培品及野生品70%醇提物的体外抑菌作用。结果:同一产地茅苍术野生品与栽培品药理作用差异较小,不同产地茅苍术野生品与栽培品之间差异较大。差异主要表现在对正常、脾虚小鼠小肠推进功能的影响及抑菌作用方面,罗田产地的作用比句容产地的好。而对无水乙醇及用0.6 mol.L-1盐酸制备的大、小鼠胃溃疡的抑制作用无明显差异。结论:在主要药效方面,茅苍术栽培品与野生品无显著差异,实验结果为茅苍术栽培品代替野生品提供一些药效学依据。

Objective： To explore the differences of the main pharmacological action in wild and cultivated Atractylodes lancea.Method： Study the effect of the 70% ethanol extracts from the wild and the culticated A.lancea on the mice with gastriculcer induced by absolute ethyl alcohol or HCl.Stdudy the effect on intestinal propulsive function in mice by measuring the length of intestine and distance of Indian ink.Observe anti-bacteria effect in vitro of the A.lancea by determining the minimum inhibitory concentrations.Result： The pharmacological action,which made a little difference in the sane productive places,and made significant differences in different productive places.Compared to Jurong,it has better actions in Luotian on small intestinal propulsive function and bacteriostatic action.There was not an obvious difference in protective effect on gastric ulcer induced by absolute ethyl alcohol and 0.6 mol·L-1 HCl between different locations.Conclusion： To the main effect,cultvated A.lancea had no significant difference on the whole but having better result in some respects,which can provide the pharmacodynamics evidence of cultivated A.lancea being used instead of the wild.