多位点微透析技术在药代动力学研究中的应用

Application of sites-microdialysis technology in pharmacokinetic studies

微透析(MD)作为一种活体生物取样技术,可以在不同组织、不同器官或同一器官不同部位进行化学取样,为阐明药物的体内过程、作用机制以及靶向性提供依据。本文介绍近年来有关多位点微透析技术在药代动力学研究领域中的应用现状和重大进展。

Microdialysis（MD）,as a living bio-sampling technique,can be utilizable in different tissues,organs or different parts of the same organs,in order to clarify the drug＇s pharmacokinetics,mechanism,and provide a basis for targeting.This article describes a number of points in recent years,the microdialysis technique in pharmacokinetic studies in the field of application of the status and significant progress.