血清同型半胱氨酸与冠心病的相关性研究

Correlation between serum homocysteine and coronary heart disease

目的探讨冠心病患者同型半胱氨酸的水平与冠状动脉病变程度的关系。方法 60例经冠状动脉造影确诊的冠心病患者,其中稳定性心绞痛18例,不稳定性心绞痛22例,急性心肌梗死20例,另选20例健康者作为对照。采集研究对象外周静脉血检测同型半胱氨酸,冠状动脉病变按Gensini评分标准。结果冠心病组患者血浆同型半胱氨酸水平与健康组相比显著增高(P<0.01);稳定型心绞痛、不稳定型心绞痛及急性心肌梗死3组同型半胱氨酸比较,水平依次降低,两两比较差异具有统计学意义(P<0.05);冠心病患者同型半胱氨酸水平在冠状动脉单支病变、双支病变、三支病变组依次增高,两两比较差异具有统计学意义(P<0.05)。同型半胱氨酸与冠状动脉病变程度呈正相关(r=0.509,P<0.01)结论血浆同型半胱氨酸水平与冠状动脉病变程度及病变支数有关,提示血浆同型半胱氨酸可作为冠心病病变程度的诊断依据。

【Objective】To evaluate relationship between serum homocysteine（HCY） level and severity of coronary artery disease in patients of coronary heart disease.【Methods】 Peripheral blood was collected to test HCY,coronary artery disease was diagnosed according to Gensini score standards.Sixty patients were diagnosed as coronary heart disease（CHD） by coronary angiography,in which there were18 patients of stable angina pectoris（SAP group）,22 cases of unstable angina pectoris（UAP group）,20 cases of acute myocardial infarction（AMI group） and 20 healthy persons（NC group） as controls.【Results】Plasma HCY level of CHD patients was significantly higher than that of NC group（P 0.05）;HCY levels of AMI,UAP,SAP groups were reduced in turn.Difference of pairwise comparison was statistically significant（P 0.05）.HCY levels in CHD patients with coronary artery single-vessel disease,double-vessel disease and three lesions were increased in turn and the difference of pairwise comparison was statistically significant（P 0.05）.HCY level and coronary artery disease were positively correlated（r =0.509,P 0.05）.【Conclusion】 The plasma HCY levels has relationship with severity of coronary lesions and the number of lesions,suggesting HCY could serve as a basis for the diagnosis of coronary heart diseases.