环氧合酶-2、血管内皮生长因子及上皮钙黏素在甲状腺癌中的表达及其临床意义

Expression and their clinical significance of COX-2, VEGF and E-cadherin in thyroid carcinoma

目的 探讨环氧合酶-2（COX-2）、血管内皮生长因子（VEGF）、上皮钙黏素（E-cadherin）在甲状腺癌中的表达及其临床病理意义.方法 采用免疫织织化学SP法检测68例甲状腺癌、16例甲状腺瘤及16例正常甲状腺组织中COX-2、E-cadherin、VEGF的表达,并对甲状腺癌组织学分型、临床病理分期及淋巴结转移进行对比分析.结果 68例甲状腺癌中COX-2、VEGF、E-cadherin的阳性表达率分别为63.2%、66.2%和60.3%,和甲状腺瘤相比较差异有统计学意义（P〈0.05）.甲状腺癌中COX-2、VEGF、E-cadherin的表达在不同临床病理分期、淋巴结转移状态差异均有统计学意义（P〈0.05）.E-cadherin与VEGF、COX-2的表达均呈负相关（r=-0.423,P〈0.01 r=-0.413,P〈0.01） COX-2与VEGF的表达呈正相关（r=0.659,P〈0.01）.结论 COX-2、E-cadherin、VEGF在甲状腺癌的发生、发展中起着重要作用,三者联合检测可为甲状腺癌恶性程度和预后的判断提供有效证据.

Objective To study the expression of COX-2,E-cadherin and VEGF in thyroid carcinoma and its clinicopathological significance.Methods Expression of COX-2,E-cadherin and VEGF was detected in 68 cases with thyroid carcinoma,16 cases with thyroid adenomas and 16 cases of normal thyroid tissue by SP immunohistochemical method.Results The expression of COX-2,E-cadherin and VEGF in 68 cases with thyroid carcinoma was 63.2%,61.8%and 66.2%,respectively,with significant difference（P〈0.05）compared with the expression of these proteins in thyroid adenomas.Expression of COX-2,VEGF and E-cadherin Was significantly different with TNM stages and with lymph node metastasis status（P〈0.05）.Expression of E-cadherin was negatively correlated to the expression of VEGF and COX-2（r=-0.423,P〈0.01 r=-0.413.P〈0.01）.Expression of COX-2 was positively related to the expression of VEGF（r=0.659,P〈0.01）. Conclusion COX-2, E-cadherin and VEGF play important roles in carcinogenesis and development of thyroid carcinoma. Combined detection can provide valuable evidence for estimation of aggressive degree and prognosis of thyroid carcinoma.