幽门螺杆菌感染与儿童特发性血小板减少性紫癜关系的Meta分析

Meta Analysis of Helicobacter Pylori Infection and Idiopathic Thrombocytopenic Purpura in Children

目的综合分析幽门螺杆菌(Hp)感染与儿童特发性血小板减少性紫癜(ITP)的关系。方法利用计算机及手工检索2000-2010年在中国期刊全文数据库、万方数据库、重庆维普及Pubmed公开发表的关于Hp感染与儿童ITP关系的病例对照研究资料,采用Meta分析方法对所有文献进行综合分析,并计算综合的OR值和95%CI。结果检索共收集相关文献35篇,排除其中研究方法不符合要求的文献,共检索有效文献8篇,其中中文文献6篇,英文文献2篇。ITP组与对照组的Meta分析结果 :OR(95%CI)为1.90(1.44～2.50),合并效应量的检验结果 Z=4.56,P=0.00001。急性ITP组与慢性ITP组的Meta分析结果 :OR(95%CI)为0.74(0.49～1.13),合并效应量的检验结果 Z=1.38,P=0.17。结论 Hp感染与儿童ITP的发病密切相关,但与ITP的类型无关。

Objective To assess the relationship between Helieobacter pylori （Hp） infection and idiopathic thrombocytopenic purpura （ITP） in children. Methods All the published literatures of relationship between Hp infection and childhood ITP were searched by computer and manual search from 2000 to 2010 in the CNKI database,WANFANG database,Chongqing Vip database and Pubmed database. A comprehensive analysis of case control studies were used by Meta analysis and calculated the value of integrated OR and 95% Cl. Results Thirty - five pertinent literatures were collected. After literature which study methods not fit the request were ruled out,there were 8 effective documents in all, including 6 Chinese literatures, and 2 English literatures. Meta analysis of OR value and 95 % Cl were 1.90 （ 1. 44 - 2.50）, and Z value of combined effect of tests was 4.56 （ P = 0. 000 01 ） in ITP group an~ control group. Meta analysis results of OR value and 95% Cl were 0.74 （0.49 - 1.13） ,and Z value of combined effect of the test was 1.38 （ = 0.17） in acute ITP and chronic： ITP group. Conclusions Hp infection is closely related with＇the incidence of ITP,but has nothing to d ：th the type of ITP.