高胆固醇血症患者缺血修饰白蛋白、血脂与炎症标志物水平关系的研究

Association between ischemia-modified albumin lipids and inflammation biomarkers in patients with hypercholesterolemia

目的考查高胆固醇血症患者缺血修饰白蛋白(IMA)、血脂及炎症标志物水平之间关系,以及IMA在动脉粥样斑块形成和氧化应激中的作用。方法检测37例动脉粥样硬化患者及37例健康志愿者血清中葡萄糖、总胆固醇、高密度脂蛋白(HDL)胆固醇、低密度脂蛋白(LDL)胆固醇、甘油三酯、氧化修饰LDL(ox-LDL)、抗ox-LDL自身抗体、高灵敏度C反应蛋白(hs-CRP)及IMA浓度。结果高胆固醇血症患者组总胆固醇、LDL胆固醇、甘油三酯、ox-LDL、抗ox-LDL自身抗体、hs-CRP及IMA水平较对照组显著增高(P<0.05),而HDL胆固醇水平较对照组显著降低(P<0.05)。IMA水平与总胆固醇、LDL胆固醇、抗ox-LDL自身抗体及hs-CRP水平之间有显著相关性。另外,hs-CRP与总胆固醇、HDL胆固醇、LDL胆固醇、甘油三酯、ox-LDL及抗ox-LDL自身抗体之间亦有显著相关性。结论高胆固醇血症与炎症标志物及氧化应激标志物的表达增高相关,并降低血清白蛋白结合钴的能力,从而导致IMA水平增高。IMA与氧化应激及动脉粥样斑块的形成有相关性,证明了其在疾病发生、发展中可能起到重要作用。

[Objective]The aim of this study was to evaluate the association between ischemia-modified albumin （IMA）, lipids and inflammation biomarkers in patients with hypercholesterolemia, and the possible involvement of IMA in atheromatous plaque development and oxidative stress. [Methods]Glucose, total cholesterol, HDL cholesterol, LDL cholesterol, triglycerides, oxidized LDL （ox-LDL）, ox-LDL autoantibodies, high-sensitivity C reactive protein （hs-CRP）, and IMA were measured in 37 subjects with hypercholesterolemia and 37 controls. [Results]Total cholesterol, LDL cholesterol, triglycerides, ox-LDL, ox-LDL autoantibodies, hs-CRP, and IMA were higher in the hypercholesterolemia group, and HDL cholesterol levels were lower in this group. We observed significant correlations between IMA and total cholesterol, LDL cholesterol, ox-LDL antibodies, and hs-CRP levels. Significant correlations were also observed between hs-CRP and total cholesterol, HDL cholesterol, LDL cholesterol, ox-LDL, oxLDL autoantibodies, and triglycerides.[Conclusion]Hypercholesterolemia is associated with an increase in inflammatory and oxidative stress biomarkers, and it also reduces the capacity of albumin to bind cobalt owing to ischemia, resulting in an increased IMA. IMA formation appears to be associated with oxidative stress and atheromatous plaque development.