碱性成纤维细胞生长因子治疗褥疮疗效观察

Clinical research of basic fibroblast growth factor for bedsore

目的探讨碱性成纤维细胞生长因子(bFGF)应用于褥疮的治疗效果。方法 120例褥疮患者,分为对照组和观察组,对照组患者采用清洁创面、无菌敷料无压力包扎,早期选用足量有效抗生素,同时给予改善微循环、营养及护理支持等常规治疗;观察组患者除常规治疗外联合应用bFGF局部喷涂,治疗1个月后,观察2组患者疗效。结果观察组总有效率(93.5%)高于对照组(50.0%)(P<0.05);治疗过程中未出现不良反应。观察组患者褥疮治愈时间短于对照组,差别有统计学意义(P<0.01)。结论 bFGF应用能明显提高褥疮患者的痊愈率和缩短治愈时间。

Objective To explore the therapeutic effect of basic fibroblast growth factor（bFGF）for bedsore,and to find a new method for bedsore in clinic.Methods One hundred and twenty patients of bedsore were divided into control group and observation group.Surfaces of wound were cleaned and bandaged with sterile dressings without pressure,adequate and effectively antibiotics were chosen in early stage,at the same time,routine therapy such as improvement of microcirculation,nutrition and nursing support were given in the control group.In addition to routine therapy and combined application with local spraying of bFGF in the observation group.The curative effects between two groups were observed after one month treatment.Results Total effective rate in observation group（93.5%）higher than that in control group（50.0%）（P0.05）.No untoward effect was found in the healing process.The cure time in observation group was shorter than that in control group,there was statistically differences between two groups（P0.01）.Conclusion Application of bFGF can obviously improve the recovery rate and short the cure time and to be worth popularizing in clinic.