某院610例Ⅰ类切口手术患者预防性应用抗菌药物分析

Analysis on Prophylactic Application of Antibiotics in 610 Patients with Type Ⅰ Incision Operation

目的:了解某院Ⅰ类切口手术预防性应用抗菌药物情况,促进临床合理用药。方法:回顾性调查某院2008年7～12月Ⅰ类切口手术患者有关抗菌药物的预防性应用情况。结果:610例患者中,有438例预防性应用抗菌药物注射剂,占71.80%。在初次给药方面,术前0.5～2h、2～48h和>48h用药者分别为39例(8.90%)、93例(21.23%)、61例(13.93%);术后用药者245例(55.94%)。在持续给药中,术后预防用药时间≤48h者65例(14.84%),术后预防用药时间3～7d者272例(62.10%)。术后单一、二联和三联用药率分别为75.34%、23.74%、0.91%。结论:该院外科Ⅰ类切口手术抗菌药物预防性应用在预防用药指征、预防用药时机、术后用药时间等方面存在不合理现象,需加强管理。

OBJECTIVE：To investigate prophylactic application of antibiotics in patients with typeⅠincision operation, and to promote rational use of drugs. METHODS： Prophylactic application of antibiotics in patients with typeⅠincision operation from Jul. to Dec. in 2008 was investigated retrospectively. RESULTS： Among 610 patients, 438 patients received antibiotic injection （71.80%）. The utilizations of antibiotics were 8.90% （39 cases）, 21.23% （93 cases）, 13.93% （61 cases）0.5～2 h, 2～48 h and more than 48 h before surgery; 55.94%（245 cases）were given antibiotics after surgery in the initial delivery time. 14.84%（65 cases）and 62.10%（272 cases）were given antibiotics below 48 h and 3～7 day after operation. After surgery, signal drug consisted of 75.34%, two-drug 23.74% and three-drug 0.91%. CONCLUSION：Clinical management of rational use of antibiotics must be enhanced because prophylactic application of antibiotics had unreasonable aspects, such as indications, prophylactic medication time, postoperative medication time.