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肠道菌群与过敏 被引量：20

Intestinal flora and allergy
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摘要 过敏性疾病是儿科常见疾病，其流行病学不是很清楚，循证医学资料倾向于环境因素的重要性。“卫生假说”认为，儿童在生命早期缺乏微生物接触是导致过敏性疾病的主要因素，且儿童体内存在Thl／Th2免疫失衡，使免疫反应更倾向于Th2应答。
作者 张琳
机构地区 河北医科大学第三医院
出处 《中国实用儿科杂志》 CSCD 北大核心 2010年第7期510-512,共3页 Chinese Journal of Practical Pediatrics
关键词 肠道正常菌群 过敏 益生菌 intestinal normal flora allergy probiotics
分类号 R72 [医药卫生—儿科]
  • 相关文献

参考文献20

  • 1Kalliomaki M, Antoine JM, Herz U, et al. Guidance for substantiating the evidence for beneficial effects of probiotics: prevention and management of allergic diseases by probiotics [J ]. J Nutr,2010,140(3):713S-72lS.
  • 2Spieckermann GM, Walker WA. Oral tolerance and its role in clinical disease [J-. J Pediatr Gastroenterol Nutr, 2001, 32: 237-255.
  • 3Bjorksten B, Sepp E, Julge K, et al. Allergy development and the intestinal microflora during the first year of life[J]. J Allergy Clin Immunnl, 2001,108: 516-520.
  • 4Schmidt WP. Model of the epidemic of childhood atopy [J]. Med Sci Monit, 2004,10(2) :5-9.
  • 5Bjorksten B, Naaber P, Sepp E, et al. The intestinal microflora in allergie Estonian and Swedish 2-year-old children [J]. Clin Exp Allergy, 1999,29 : 342-346.
  • 6Kalliomaki M, Kirjavainen P, Eerola E, et al. Distinct patterns of neonatal gut microflora in infants in whom alopy was and was not developing[J]. J Allergy Clin Immunol,2001,107 : 129-134.
  • 7Penders J, Thijs C, van den Brandt PA, et al. Gut microbiota composition and development of atopic manifestations in infancy : the KOALA birth cohort study [ J ]. Gut, 2007,56 : 661-667.
  • 8刘崇海,杨锡强,刘春花,何云,王莉佳.变应性气道反应与抗生素诱导的肠道菌群失调关系研究[J].中华儿科杂志,2007,45(6):450-454. 被引量：39
  • 9Bjorksten B. Evidence of probioties in prevention of allergy and asthma [J]. Curr Drug Targets Inflamm Allergy, 2005, 4 (5) : 599-604.
  • 10Kalliomaki M, Salminen S, Arvilommi H, et al. Probiotics in primary prevention of atopic disease: a randomised place- bo-controlled trial[ J ]. Lancet, 2001,357 : 1076-1079.

二级参考文献9

  • 1梁庆红,张琳,段恕诚,王沛,张亚超,骆金芝,庞英.肠道菌群失调对小鼠免疫和造血功能状态的影响[J].中华儿科杂志,2004,42(9):708-711. 被引量：29
  • 2Ahn KM, Lee MS, Hong SJ, et al.Fever, use of antibiotics, and acute gastroenteritis during infancy as risk factors for the development of asthma in Korean school-age children. J Asthma, 2005,45:745-750.
  • 3Johnson CC, Owhby DR, Afford SH, et aL Antibiotic exposure in early infancy and risk for children atopy. J Allergy Clin Immunol, 2005,115 : 1218-1224.
  • 4Noverr MC, Noggle RM, Toews GB, et al.Role of antibiotics and fungal microbiota in driving pulmonary allergic responses. Infect lmmun, 2004,72:4996-5003.
  • 5Li R, Yang XQ, Wang l.J, et al.Respiratory syncytial virus infection reversed anti-asthma effect of neonatal bacillus calmetteguerin vaccination in BALB/c mice. Pediatric Research, 2006, 59:210-215.
  • 6Miettinen M, Matikainen S, Vuopio-Varkila J, et al.Lactobacilli and streptococci induce interleukin-12 ( IL-12 ), IL-18, and gamma interferon production in human peripheral blood mononuclear cells. Infect Immun, 1998,66:6058-6062.
  • 7Oyama N, Sudo N, Sogawa H, et aL Antibiotic use during infancy promotes a shift in the T ( H ) 1/T ( H ) 2 balance toward T ( H ) 2- dominant immunity in mice. J Allergy Clin Immunol, 2001, 107: 153-159.
  • 8Ronning CM, Fedorova ND, Bowyer P, et aL Genomics of Aspergillusfumigatus. Rev Iberoam Micol, 2005,22:223-228.
  • 9Szabo SJ, Kim ST, Costa GL, et aL A novel transcription factor, T-bet, directs Th1 lineage commitment.Cell, 2000, 100 : 655- 669.

共引文献38

同被引文献326

引证文献20

二级引证文献171

中国实用儿科杂志
2010年 第7期

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