非诺贝特和吡格列酮对代谢综合征大鼠血压及体重的影响

Effect of Fenofibrate and Pioglitazone on Blood Pressure and Body Weight in Rats With Metabolic Syndrome

目的:探讨非诺贝特和吡格列酮对高果糖诱导的代谢综合征(MS)大鼠血压及体重的影响。方法:用高果糖饮食饲养SD大鼠构建MS大鼠模型,将存活的大鼠随机分为空白对照组(n=8),代谢综合征模型组(n=39)。又将代谢综合征模型组分为4个亚组:模型对照亚组(n=10),非诺贝特亚组(n=8),吡格列酮亚组(n=11),非诺贝特+吡格列酮亚组(n=10)分别单用非诺贝特和吡格列酮及二者合用干预。分析比较两种药物单用及合用,对MS大鼠收缩压、体重等的影响。结果:吡格列酮亚组干预后与干预前比收缩压降低(P<0.01),胰岛素敏感指数(ISI)升高(P<0.01)。非诺贝特亚组干预后与干预前比收缩压、ISI变化均不明显(P>0.05)。非诺贝特+吡格列酮亚组干预后与干预前比收缩压降低,ISI升高(P均<0.01),差异有统计学意义。干预后,各药物干预亚组与模型对照亚组间体重差异无统计学意义(P>0.05)。结论:单用吡格列酮或合用非诺贝特干预明显改善MS大鼠胰岛素抵抗、降低收缩压,可更好地控制其心血管病的危险因素。

Objective ： To explore the effect of pioglitazone and fenofibrate on systolic blood pressure and body weight in the fructose-induced metabolic syndromic （MS） rats. Methods ： SD rats were divided into Blank control group （ n = 8 ） , the rats were fed with the regular diet, and MS group （n = 39） , the rats were fed with high fructose diet to establish the MS model. The MS rats were further devided into 4 subgroups as Control group （n = 10） , Fenofibrate group （n = 8） , Pioglitazone group （n = 11 ） and Combination group （n = 10） , in whick Fenofibrate and Pioglitazone were used together. Fenofibrate or Pioglitazone and their combination was applied to MS rats respectively. The systolic blood pressure, body weight and insulin sensitivity index （ISI） of MS rats were analized and compared among groups. Results： In Pioglitazone group,the systolic blood pressure was decreased and ISI was increased,while in Fenofibrate group, the changes of systolic blood pressure and ISI was not significant. In Combination group, the systolic blood pressure was decreased and the ISI were increased. All medications showed no real effect on the body weight of MS rats. Conclusion ： Pioglitazone alone or the combination of Fenofibrate and Pioglitazone could decrease the systolic blood pressure and increase ISI in MS rats. Those effect could better control the risk factors of cardiovascular disease.