单纯性肥胖儿童24小时尿微量蛋白检测的临床意义

Clinical Significance of Examination of 24 h Urinary Microprotein in Children with Simple Obesity.

目的 探讨单纯性肥胖对肾脏功能的损伤。 方法 ＲＩＡ 检测７１ 例单纯性肥胖儿童２４ 小时尿中微量ＡＩｂ 、ＩｇＧ、β２ － Ｍ 及ＴＨＰ 的含量。 结果 ７１ 例肥胖儿童尿中ＡＩｂ 含量分别与ＢＭＩ、收缩压及血清胆固醇呈显著正相关。 结论 肥胖引起的肾功能早期改变使尿ＡＩｂ 、ＩｇＧ 排泄量增加。

Objective To study the effect of simple obesity on renal function. Methods The amounts of 24 hr urinary excretion of albumin(Alb),IgG,β 2-m and tamm horstall protein (THP) were assaied by RIA in 71 simple obese children and 37 normal children. Rusults The amounts of 24 hr urinary excretion of Alb and IgG were increased significantly compared to normal control,and the level of 24 hr urinary Alb was positively correlated with the levels of serum cholesterol,systolic pressure and body mass index(BMI) respectively. Conclusion The level of 24 hr urinary albumin is the early index of the renal injury in obesity.