纤维蛋白原在治疗新生儿DIC中的临床作用

Treatment of DIC in Neonates Using Fibrinogen.

目的 探讨静脉注射纤维蛋白原制剂在新生儿弥漫性血管内出血（ＤＩＣ） 治疗中的作用。 方法 ５７ 例新生儿ＤＩＣ病人随机分为治疗组、对照组，静滴纤维蛋白原６ 小时后观察临床表现及凝血指标。 结果 比较治疗组与对照组凝血指标，治疗组６ 小时内止血效果优于对照组（ Ｐ＜ ０ ．０５） ；治疗组与对照组ＤＩＣ抢救成功率比较，治疗组明显高于对照组（ Ｐ＜ ０ ．０５） 。 结论 静脉注射纤维蛋白原制剂在新生儿ＤＩＣ 出血期的治疗中能加快止血，对抗纤溶，提高抢救成功率。

Objective To observe the efficacy of fibrinogen in the treatment of DIC in neonates Methods 57 newborn patients with DIC were divided in 2 groups,experimental(A)and control(B).Clinic manifestations and coagulation function of 2 groups were investigated six hours after the fibrinogen were injected into the patients. Results Compared the coagulation function of the 2 group,patients in group A were better than in group B 6 hours( P <0.05).And the cure rate of group A was higher than in group B. Conclusion Intravenous injection of fibrinogen improved the coagulation in neonate patients with DIC.The therapy efficacy of fibrinogen is approved.