麻醉药物药效学相互作用研究方法新进展

Advances in the methodology for pharmacodynamic interaction of anesthetics

随着科技的发展,药物相互作用的研究水平有了较大的提高,在研究药物相互作用的试验设计、研究手段及研究方法等方面有了较大进展。在研究麻醉药物药效学相互作用的多种方法中,一些方法仅能定性地研究麻醉药物间药效学的作用规律;响应曲面分析法是一种新颖而有效的研究麻醉药物相互作用的方法,它不仅可以定性和定量地研究麻醉药物间的药效学相互作用的规律,而且还可以寻找到麻醉效果满意、不良反应最小的药物间的最佳阈值反应范围。文中对近年来麻醉药物药效学相互作用研究方法的新进展进行综述。

With the development of science and technology,the research of drug interaction has been greatly improved,such as design of studies,techniques and methods in drug interaction. Among a variety of research methods in pharmacodynamic interaction of anesthetics,some methods can only characterize the pharmacodynamic interactions qualitatively. As a novel and effective approach,response surface method is used in the study of anesthetics interaction. Response surface method can characterize the pharmacodynamic interactions of anesthetics qualitatively and quantitatively. Moreover,computer can stimulate the identify concentration pairs of anesthetics that provided more synergy,adequate anesthetic effects and minimal side effects. In this article,we reviewed advances in the research methodology for pharmacodynamic interaction of anesthetics in recent years.