缬沙坦致不良反应74例文献分析

Adverse reactions induced by valsartan:analysis of 74 cases

目的:探讨缬沙坦不良反应发生的特点及规律,为临床合理用药提供参考。方法:通过对维普数据库和中国知网进行检索,并查阅原始文献,对2000-2009年国内期刊报道的74例缬沙坦所致不良反应进行统计分析。结果:缬沙坦的不良反应主要有头晕、头痛、刺激性干咳、血管神经性水肿、胃肠道反应、首剂低血压、一过性低血压、关节痛等。结论:临床医师应关注缬沙坦所致的不良反应,以确保临床用药安全、合理、有效。

Objective：To evaluate the patterns and characteristics of adverse reactions induced by valsartan and to provide guidance for its rational use in clinic. Methods：A total of 74 patients with adverse reactions induced by valsartan were retrieved and analyzed statistically. These cases were reported in domestic pharmaceutical journals between 2000 and 2009,and searched from VIP Database and CNKI. Results：The main adverse reactions induced by valsartan included dizziness,headache,dry cough,acute circumscribed edema,gastrointestinal tract reactions,hypotension,and arthralgia. Conclusion：Clinicians should pay attention to adverse reactions induced by valsartan to ensure rational,safe and effective use of valsartan.