血清IL-8、hsCRP和TNF-α水平与冠心病患者冠脉病变相关性的研究

Relationship between serum IL-8,hsCRP,TNF-α and coronary lesions in CHD patients

目的：观察血清炎症因子白细胞介素-8（IL-8）、超敏C反应蛋白（hsCRP）和TNF-α与冠状动脉病变的关系。方法：入选经选择性冠状动脉造影（CAG）确诊为冠心病的患者106例（冠心病组），另选择同期健康体检人群为正常对照组（n=100）。用酶联免疫吸咐法（ELISA）检测血清IL-8、散射光比浊法测定hsCRP和放射免役法检测TNF-α的水平。用改良的Gensini评分评价冠心病患者冠脉病变程度。结果：冠心病组血清IL-8、hsCRP和TNF—α水平明显高于正常对照组（P〈0．05）。随着Gensini评分增加，IL-8、hsCRP和TNF-α水平逐渐升高（趋势P〈0．05）。Pearson相关分析显示，冠心病组Gensini评分与IL-8（P〈0．05）、hsCRP（P〈0．05）和TNF—α（P〈0．05）呈正相关。结论：冠心病患者冠脉病变程度与血清炎症因子IL-8、hsCRP和TNF—α水平相关。

AIM： To study the relationship between serum inflammation factors interleukin-8 （IL-8）, high-sensitivity C-reactive protein, tumor necrosis factor-α and coronary lesions in coronary heart disease （CHD） patients. METHODS： One hundred and six CHD patients were enrolled, 100 healthy subjects served as control group. The levels of serum IL-8, hsCRP（by ） and TNF-α were determined. Coronary lesions were caculated by Gensini method. RESULTS： The levels of serum IL-8, hsCRP and TNF-α in CHD group were significantly higher than those in control group （ P 〈 0.05）, and serum IL-8, hsCRP and TNF-α in CHD group increased gradually with the increase of Gensini score（ P 〈 0.05）. Pearson correlation analysis showed that Gensini score was positively correlated to IL-8 （ P 〈 0.05 ）,hsCRP（ P〈 0. 05 ） and TNF-α （ P 〈 0. 0.5 ） in CHD group. CONCLUSION： Severity of coronary lesions in CHD patients may be related to the levels of serum IL-8, hsCRP and TNF-α.