手性联萘酚催化辛炔与苯甲醛的不对称加成反应研究

Study on Asymmetric Addition of Octyne and Benzaldehyde Catalyzed by Chiral 1,1'-bi-2-naphthol

手性炔丙醇是合成许多天然产物和药物的重要中间体.报道了手性联萘酚催化辛炔与苯甲醛的不对称炔基锌加成反应,在室温下产物产率为91%,对映体过量为53%,为脂肪炔丙醇的对映选择性合成提供了一个新的方法.

Chiral propargyl alcohol is an important intermediate for syntheses of many natural products and pharmaceutical compounds. Enantioselective 1Octyne addition to benzaldehyde catalyzed by chiral 1,1′bi2naphthol（BINOL） is first reported. In this addition, the yield is 91% at room temperature the enantio morph excess is 53%, which gives a new methods for enantioselective synthesis of aliphatic propargyl alcohol.