两型脑卒中患者载脂蛋白E基因型的分布比较

Comparison of Apolipoproteins E Genotype Distribution in Two Type of Stroke

为了解载脂蛋白Ｅ基因型与两型脑卒中的关系，采用聚合酶链反应技术对９０例脑出血和９０例脑梗死患者及其１０７例性别、年龄配对的对照者进行载脂蛋白Ｅ基因型检测。结果发现脑出血患者载脂蛋白Ｅε２／ε３基因频率高于对照组（Ｐ＜０．０５），而载脂蛋白Ｅε３／ε３基因频率在对照组较高（Ｐ＜０．０５）。脑梗死患者中载脂蛋白Ｅε４携带频率较对照组显著增高（Ｐ＜０．０５）。研究结果表明载脂蛋白Ｅε２可能与出血性脑卒中有关，而载脂蛋白ε４为缺血性脑卒中的重要遗传标志。

Aim To evaluate the apolipoprotein E (Apo E) genotype distribution in two type of stroke. Methods Polymerase chain reaction restriction segment length polymorphism (PCR RFLP) wae used to examined the Apo E genotype in 180 patients with hemorrhagic stroke (90) and ischemic stroke (90), along with the 107 age and sex matched controls. Results The frequency of Apo E ε2/ε3 was higher in hemorrhagic stroke group (28.9%) than in the controls (16.7%, P<0.05), while the Apo E ε3/ε3 frequency was lower in the cases (54.4%) than in the controls (70.0%, P<0.05). The Apo E ε3/ε4 was more frequent in the ischemic stroke group (21. 1%) than in the controls (8.9%, P<0.05). Conclusion Apo E ε2 may be related to the risk of hemorrhagic stroke and that Apo E ε4 may be an important risk factor for ischemic stroke.