缺失型血管紧张素转化酶基因与陈旧性心肌梗死患者胰岛素抵抗的关系

Relation Between Insulin Resistance and Deletion Polymorphism of the Angiotensin Converting Enzyme Gene in Patients with Old Myocardial Infarction

为探讨缺失型血管紧张素转化酶基因与陈旧性肌梗死患者胰岛素抵抗水平间的关系，本文选择５５例陈旧性心肌梗死患者和４７例普外科住院病人为对照组。用血浆空腹血糖浓度×血浆空腹胰岛素浓度÷２２．５计算胰岛素抵抗。用聚合酶链反应技术检测血管紧张素转化酶基因缺失／插入多态性。结果发现，陈旧性心肌梗死患者胰岛素抵抗水平和缺失型血管紧张素转化酶基因频率较对照组无统计学差异（Ｐ＞０．０５）。陈旧性心肌梗死患者血管紧张素转化酶缺失纯合型、杂合型及插入纯合型基因型之间的胰岛素抵抗水平无统计学差异（Ｐ＞０．０５）。结果提示，缺失型血管紧张素转化酶基因和胰岛素抵抗与冠心病无联系，且它们之间不存在协同作用。

Aim To explore the relation between insulin resistance (IR) and deletion polymorphism of angiotensin converting enzyme(ACE)gene in patients with old myocardial infarction. Methods The insulin resistance was calculated by fast plasma insulin × fast plasma glucose÷22.5; The deletion (D)/insertion(I) polymorphism of the ACE gene was determined by polymerase chain reaction in 55 patients with old myocardial infarction and in47 control subjects. Results The insulin resistance level did not increase significantally in patients with old myocardial infarction, compared with control subjects(P>0.05); There were not significant difference of IR level among ACE DD、DI、Ⅱ gene types in the old myocardial infarction group(P>0.05 ). Conclusions The association of deletion polymorphism of ACE gene and IR with coronary heart disease were not found. The relation between deletion polymorphism of ACE gene and IR was also not identified in patients with coronary heart disease.