参麦注射液防治兔油酸型急性呼吸窘迫综合征的实验研究

EXPERMENTAL STUDY OF EFFECT OF SHEN MAI INJECTION ON ACTUE RESPRIATORY DISTRESS SYNDROME BY OLEIC ACID IN RABBITS

目的：观察静注参麦注射液对实验性油酸型急性呼吸窘迫综合征（ＡＲＤＳ）的影响。方法：静脉注射油酸（０．１ｍｌ／ｋｇ）复制家兔ＡＲＤＳ的动物模型，随后立即静脉注射参麦注射液（１０ｍｌ／ｋｇ），观察在ＡＲＤＳ发展过程中白细胞介素－１（ＩＬ－１）、肿瘤坏死因子（ＴＮＦ）、血气，２ｈ后处死动物检测肺组织匀浆ＩＬ－１、ＴＮＦ活性及病理改变，并与模型组做比较。结果：参麦注射液可明显缓解油酸所致的急性肺损伤，改善低氧血症，经统计学处理后治疗组与模型组相比，血浆ＩＬ－１，ＴＮＦ在１２０ｍｉｎ（Ｐ＜０．０５），肺组织匀浆ＩＬ－１、ＴＮＦ治疗组与模型组相比较亦降低（Ｐ＜０．０５）。结论：提示参麦注射液可明显减轻所致的急性肺损伤。

Objective:To observe the effect of Shen-Mai injection on experimental acute respiratory distress syndrome (ARDS) induced by oleic acid Methods:ARDS animal model was prepared in rabbits by iv oleic acid (0 1ml/kg), then iv Shen-Mai injection (10ml/kg) and plasma interleukin-1 (IL-1), tumor necrerosis factor (TNF) activity in different time points and pathologic changes were observed and compared to control group Results:The acute lung injury induced by oleic acid was decresed; hypoxemia was improved; the IL-1 and TNF activity in plasma and lung tissue homogenates were decresed in treatment group, it was superior to those in oleic acid group ( P <0 05) Conclusion:Shen-Mai injection can alleviate the acute lung injury induced by oleic acid, so it has some action on preventing and treating experimental ARDS