比索洛尔联合厄贝沙坦治疗慢性心力衰竭(附65例分析)

Clinical Observation of Bisoprolol Combined with Irbesartan on 65cases with Chronic Heart Failure

目的:探讨比索洛尔联合厄贝沙坦治疗慢性心力衰竭疗效。方法:选择我院2007-10～2009-10慢性性充血性心力衰竭患者127例,将以上患者随机分为观察组和对照组。两组均予常规强心、利尿、扩血管抗心衰治疗。对照组加服厄贝沙坦75～150mg/次,1次/d;观察组厄贝沙坦75～150mg/次,1次/d,待病情稳定后再加服比索洛尔初始剂量1.25mg,1次/d,根据患者可以耐受程度8周内逐渐增加剂量,每周增加1.25mg,增加到最大剂量为10mg,1次/d。两组患者共治疗8周。结果:观察组的总有效率与对照组的总有效率比较,差异有统计学意义(P<0.05)。结论:比索洛尔联合厄贝沙坦治疗慢性心力衰竭,临床治疗效果显著。

Objective：To explore the clinical efficacy of bisoprolol combined with irbesartan on chronic heart failure.Methods：127 cases with chronic heart failure were selected from October,2007 to October,2009,and they were divided into two groups,observation group and control group.routine therapy（cardiac effect、diuresis、vasodilative） was used to the two groups,irbesartan（75 ～ 150 mg） was used to control group one time a day;irbesartan（75 ～ 150 mg） was used to observatio group one time a day,when the state was stable,bisoprolol was used to the control group,the initial dose was 1.25 mg one time a day,according to the tolerance,the dose was increased in 8 weeks,1.25 mg was increased every week,and the maximum dose was 10mg one time a day.the course was 8 weeks in two groups.Results：the total rate of clinical efficacy in observation group compared with the total rate of clinical efficacy,there was statistical difference（P 0.05）.Conclusions：Clinical efficacy of bisoprolol combined with irbesartan on chronic heart failure is significant,and the therapy should be the reference for doctors.