颅脑创伤后血液表观粘度的变化

THE CHANGES OF THE BLOOD APPARENT VISCOSITY FOLLOWING TRAUMATIC BRAIN INJURY

目的：观察颅脑创伤后血液粘度的变化。方法：以ＰＢⅠ—Ⅱ型损伤装置制成兔中度颅脑创伤，采集伤后１ｈ，６ｈ，２４ｈ的血样，用Ｌｏｗ Ｓｈｅａｒ３０测量表观粘度，同时测红细胞压积。比较创伤组和对照组的表观粘度、还原粘度、乘幂函数系数及计算的红细胞压积为４０％时的表观粘度。结果：乘幂函数描述血液表观粘度可有效地消除红细胞压积的影响。颅脑创伤后１ｈ其血液粘度即明显增加，伤后６ｈ持续增加，伤后２４ｈ较伤后６ｈ明显下降。与对照组相比，颅脑创伤后血液粘度的增加在低切下更为明显。结论：乘幂函数描述血液表观粘度是可行有效的方法，颅脑创伤后血液粘度的变化可能在继发性脑损伤中起一定作用，提示可用降低血液粘度的药物治疗颅脑创伤。

Objective: The changes of the blood apparent viscosity following traumatic brain injury were observed. Methods;The moderate brain trauma of rabbits was produced with the FBI -Ⅱ type injury device. The blood samples at 1hr,6hr and 24hr following brain trauma were collected. The apparent viscosity was measured with the Low Shear 30,and the hematocrit was measured at the same time. The apparent viscosity,reductive viscosity, coefficient of the power function and the calculative apparent viscosity while the hematocrit was 40% ,were compared. Results;the blood apparent viscosity described by the power function is effective in eliminating hematocrit's interference, and The blood viscosity is significantly increased at 1hr after brain trauma,it is increased continually at 6hr, the blood viscosity at 24hr is distinctly decreased than at 6hr. It is more increased after brain trauma at low shear than control group. Conclusion :The power function method is a feasible and effective method to describe the blood apparent viscosity. The changes of the blood viscosity after brain trauma may play a role in the occurrence of the secondary brain damage, which indicated that the traumatic brain inury can be treated with the drugs which can decrease the blood viscosity.