血清β-HCG、HPL和β-HCG/HPL比值对妇产科疾病的临床意义

Clinical Significance of Serum β-HCG, HPL Levels and β-HCG/HPL Ratio in Gynecological and Obstetric Diseases

本文用放射免疫分析测定了妇产科疾病患者血清β－HCG、HPL和β－HCG／HPL比值，并以正常孕妇作对照。结果表明：正常孕妇血清β－HCG和HPL随妊娠时间的增加逐步增高，而滋养细胞肿瘤即葡萄胎和绒毛膜上皮癌患者，血清β－HCG随着恶性程度的增高而增加（P＜0．01），而血清HPL随着恶性程度的增高而降低（P＜0．05），β－HCG／HPL比值高达15000以上（P＜0．001）；宫外孕的孕妇血清β－HCG较之同期孕妇明显降低（P＜0．05），β－HCG／HPL比值明显增加（P＜001）。高危妊娠（包括妊高征、胎儿宫内发育迟缓、胎儿宫内窘迫、母儿血型不合。胎盘病变和高龄产妇妊娠晚期）患者血清HPL明显下降。为了分娩前采取积极的治疗措施，我们以HPL＜4μg／mL作为高危妊娠的警戒线。

To determine serum β - HCG, HPL levels and the β - HCG/HPL ratio in patientswith gynecological and obstetric diseases and compared them with those of normal pregnantwomen. The results showed that the levels of serum β - HCG and HPL elevated along with the increase of gestation time in normal pregnant women. The level of serum β - HCG elevated alongwith the increace of degree of malignacy (P < 0. 01 ), while the level of serum HPL lowered alongwith the dogree of malignancy (P < 0. 05), and the β - HCG/HPL ratio was as high as above15000 (P < 0. 01 ) in patients with hydatid mole or chorionie epithelioma. In patients with extra uterine pregnancy the level of serum β - HCG was significantly lower than that of normal pregnantwomen with the same gestation time as the fomer (P < 0. 01 ). In patients with high - risk pregnancies including hypertension of pregnancy, retardation of intrauterine fetal growth, fetus respiratory distress syndrome, blood group incompatibility between fetus and the mother, placentadegeneration, and elderly primiparity the level of serum HPL reduced significantly. In order totake active therapeutic measures before delivery, the level of HPL below 4 μg/mL should be takenas the warning mark.