银杏内酯对心肌缺血犬血流动力学的影响

Effects of Ginkgolide on Hemodynamics in Myocardial Ischemic Dogs

目的:研究银杏内酯(Ginkgolide,Gin)对心肌缺血犬血流动力学的影响。方法:结扎冠状动脉前降支建立犬心肌梗死模型,观察银杏内酯十二指肠给药后对急性心肌缺血犬的血流动力学参数及心肌耗氧量的影响。结果:Gin(4.5、9.0、18.0mg/kg)能在不同的时点升高心肌缺血犬左室收缩末压(LVSP)、左室最大收缩速率(+dp/dtmax)、左室做功指数(LVWI)、每搏功(SW)、心输出量(CO)、冠脉血流量(CBF),降低总外周阻力(TPVR)、冠脉阻力(CVR)、心肌耗氧量(MVO2)和心肌氧摄取率(MOUR)。结论:Gin对心肌缺血犬血流动力学和心肌氧代谢具有一定的改善作用。

Objective：To investigate the effects of Ginkgolide on hemodynamics and myocardial oxygen metabolism in acute myocardial ischemic dogs.Methods：Acute myocardial ischemic model dogs were established by ligating left anterior descending coronary artery（LAD）.Some hemodynamic parameters and cardiac oxygen consumption were observed after Ginkgolide were given to dogs through the duodenum.Results：Ginkgolide could increase LVSP,＋dp/dtmax,LVWI,SW,CO and CBF,decrease TPVR,CVR,MVO2 and MOUR of Acute myocardial ischemic model dogs at different time points after ligation of LAD.Conclusion：Ginkgolide can improve the hemodynamic conditions and oxygen metabolism of myocardial ischemic dogs.