复方崩大碗灌肠剂对慢性肾功能衰竭大鼠肾脏系数、电解质和血液的影响

Effects of Compound Centella asiatica Enema on Kidneys Coefficient,Electrolytes and Blood in Chronic Renal Failure Rats

目的:研究复方崩大碗灌肠剂治疗慢性肾功能衰竭(CRF)的药理作用。方法:除空白对照组外各组大鼠以含0.5%腺嘌呤饲料喂养,剩余大鼠建立大鼠CRF模型,将造模大鼠分为模型组、尿毒清阳性对照组及复方崩大碗灌肠剂高、中、低剂量组并给予相应药物治疗30d后,采集血液、肾脏标本,计算肾脏系数,检测电解质水平及红细胞压积(HCT)、红细胞计数(RBC)、血红蛋白(HGB)的含量。结果:与模型组比较,复方崩大碗高剂量组与尿毒清对照组CRF大鼠血清电解质显著改善,且HCT、RBC、HGB的含量显著升高。结论:高剂量复方崩大碗灌肠剂对腺嘌呤所致CRF大鼠有显著的治疗作用。

Objective：To study the pharmacological effects of compound Centella asiatica enema on chronic renal failure（CRF）rats.Methods：Rats were divided into control group,CRF model group,Niaoduqing positive control group,compound Centella asiatica enema high、middle and low three groups kidney coefficient,electrolyte levels,hematocrit（HCT）,red blood cell counts（RBC）,hemoglobin（HGB）content were observed after 30 days＇s treatment.Results：Compared with the model group,the level of the electrolyte,HCT,RBC,HGB of rats in compound Centella asiatica enema high-doses group and the Niaoduqing group were significantly improved.Conclusion：High-doses of compound Centella asiatica enema has signifcant therapeutic effect on CRF rats.