腹膜播散型胃癌术后腹腔化疗21例报道

AN ANALYSIS OF POSTOPERATIVE INTRAPERITONEAL CHEMOTHERAPY FOR PERITONEAL CARCINOMATOSIS IN TWENTY ONE PATIENTS WITH GASTRIC CANCER

目的探讨腹膜播散型胃癌姑息性胃切除后腹腔化疗的价值。方法２１例腹膜播散型胃癌姑息性胃切除后腹腔内５ＦＵ１ｇ化疗，每天一次连用５天为１疗程，每月重复，６个疗程后结束化疗。并与１５例腹膜播散型胃癌姑息性胃切除后静脉化疗相比较。结果腹腔化疗组无明显毒副反应，术后一年、二年的生存率分别为８０７％、４７１％，对照组生存率为５６５％、１４３％。治疗组的一年、二年生存率明显高于对照组（Ｐ＜００１）。结论腹腔化疗毒副反应少，是腹膜播散胃癌姑息性胃切除后较好的辅助治疗措施。

PURPOSE The results of postoperative intraperitoneal chemotherapy for peritoneal cacinomatosis in gastric cancer after palliative gastrectomy were assessed.METHODS Fluorouracil was administered to 21 patients with peritoneal carcinomatosis who underwent palliative gastrectomy for the peritoneal perfusion.RESULTS The side effect was not serious in patients who received the intraperitoneal chemotherapy.The 1 and 2 year survival rates was 80.7% and 47.1% respectively for the 21 patients who received intraperitoneal perfusion compared to 56.5% and 14.3% respectively for those who only received intravenous chemotherapy( P <0 01).CONCLUSION It is recommended that postoperative intraperitoneal chemotherapy be administered to patients with advanced gastric cancer after palliative gastrectomy.