胃癌的发生与幽门螺杆菌感染的相关性研究

INTERRELATED RESEARCH ON OCCURRENCE OF STOMACH CANCER AND INFECTION OF HELICOBACTER PYLORI(HP)

目的探讨幽门螺杆菌（ＨＰ）与胃癌的发生关系。方法分别对２７名胃癌患者和３０名胃镜检查为慢性胃炎者进行ＨＰ检测。结果胃癌组ＨＰ阳性率高于对照组（Ｐ＜００５）。胃癌组随年龄增长ＨＰ感染率增高（Ｐ＜００１）。早期胃癌感染率高于进展期胃癌（Ｐ＜００５）。肠型胃癌ＨＰ感染率明显高于弥漫型及混合型胃癌（Ｐ＜００１）；非贲门部胃癌ＨＰ感染率高于贲门部胃癌（Ｐ＜００５）。结论胃癌的发生与ＨＰ感染有密切相关性。老年人尤易患ＨＰ感染；支持ＨＰ感染→活动性胃炎→癌前期病变→胃癌的发生模式。

PURPOSE Probe into the relationship between the occurrence of stomach cancer and infection of HP.METHODS Giving HP check to twenty seven patients who have stomach cancer and thirty patients who have long period gastritis by gastroscopy.RESULTS HP check rate from group of stomach cancer is higher than that from the contrast group( P <0 05),which is increasing with ages( P <0 01);HP check rate of early stage cancer of stomach is higher than that of developing stage stomach cancer; the rate of belly stomach cancer is higher than that of spread and mixed stomach cancer( P <0 01); the rate of non cardiac stomach cancer is higher than that of cardiac stomach cancer( P <0 05).CONCLUSION Occurrence of stomach cancer is closely interrelated to infectiom of HP.The aged people are easy to suffer from HP infection.The developing pattern is supported formed proved to be true.That is,HP infection→movable(active)→gastritis→early stage stomach cancer→stomach cancer.