摘要
伊布利特是一种Ⅲ类抗心律失常药,主要用于心房颤动或扑动。伊布利特的严重不良反应之一为心律失常,表现为QT间期延长和尖端扭转性室性心动过速(TdP)。TdP一般发生于用药后1h内。伊布利特引致TdP的机制可能和复极异常有关。防治伊布利特所致心律失常措施如下:一旦出现心律失常应立即停药,电击复律,给予异丙肾上腺素、阿托品,补钾和镁,并可给予β受体阻滞剂;电解质异常患者用药前应纠正电解质;伊布利特应避免和其他抗心律失常药联用;用药期间宜进行心电监测;女性患者应用伊布利特比男性易出现心律失常,应予注意。
Ibutilide is a class Ⅲ antiarrhythmic used in the treatment of atrial fibrillation or flutter. One of the serious adverse reactions to ibutilide is arrhythmias,manifested as QT interval prolongation and torsade de pointes （ TdP ） . The time to TdP onset is within 1 hour after drug administration. The mechanism of ibutilide-induced TdP may be related to the repolarization abnormalities. The measures of prevention and treatment of ibutilide-induced arrhythmias are as follows： if arrhythemias occures,the drug showed be withdrawn immediately,electrical cardioversion,isoprenaline and atropin injections,potassium and magnesium supplements as well as beta blockers should be given; electrolyle abnormalities should be corrected before treatment strart; concomitent use of ibutilide with other antiarrhythmics should be avoided; ECG monitoring should be carried out during ibutilide treatment; Ibutilide-induced arrhythmics is liable to occure in women than men,and caution is needed when using ibutilide in women.
出处
《药物不良反应杂志》
2010年第3期188-193,共6页
Adverse Drug Reactions Journal
关键词
伊布利特
不良反应
心律失常
防治
Ibutilide
aderse reactions
arrhythmia
prevention and treatment
