摘要
4例患者(3例男性,1例女性,年龄22～60岁)分别诊断为病毒性脑炎、症状性癫痫、三叉神经痛和脑出血,服用卡马西平0.1～0.2g,3次/d。1个月内均出现神志淡漠、嗜睡、食欲不振等,血钠水平分别从141.0、143.0、141.6和139.8mmol/L降至122.2、112.1、121.8和116.6mmol/L。4例患者遂即停用卡马西平,换用其他药物并接受对症支持治疗。1周后血钠水平分别恢复至138.0、144.0、139.2和144.2mmol/L。
Four patients （ three men and one woman aged 22-60 years） were diagnosed as having viral encephalitis,symptomatic epilepsy,trigeminal neuralgia and cerebral hemorrhage,respectively. They received carbamazepine 0. 1-0. 2g three times daily. Within one month after starting carbamazepine,they developed apathy,somnolence and anorexia. Their serum sodium levels decreased from 141. 0,143. 0,141. 6 and 139. 8mmol/L to 122. 2,112. 1,121. 8 and 116. 6 mmol/L,respectively. Carbamazepine was withdrawn and changed to other drugs. Meanwhile the patients received symptomatic and supportive therapies. Their levels of serum sodium returned to 138. 0,144. 0,139. 2 and 144. 2 mmol/L,respectively.
出处
《药物不良反应杂志》
2010年第3期206-208,共3页
Adverse Drug Reactions Journal
关键词
卡马西平
不良反应
低钠血症
carbamazepine
adverse reactions
hyponatremia
