卡托普利和氯沙坦对血管性痴呆模型大鼠学习记忆的影响

Effect of captopril and losartan on the ability of learning and memory of rats with vascular dementia

目的观察卡托普利和氯沙坦对血管性痴呆模型大鼠的治疗作用。方法从雄性SD大鼠50只中,随机选40只采用间断性结扎大鼠双侧颈总动脉法,建立血管性痴呆动物模型,造模成功的30只又随机分为卡托普利组、氯沙坦组和模型组,每组10只;未造模的10只大鼠为假手术组。应用Morris水迷宫实验检测各组大鼠学习记忆能力。结果与假手术组比较,模型组大鼠逃避潜伏期明显延长,穿越平台次数明显减少(P<0.05);与模型组比较,卡托普利组大鼠第1天起和氯沙坦组大鼠第2天起逃避潜伏期明显缩短,穿越平台次数明显增多(P<0.05)。结论卡托普利和氯沙坦均具有改善血管性痴呆模型大鼠学习记忆能力的作用。

Objective To observe the effect of captopril and losartan on the ability of learning and memory of the rats with vascular dementia. Methods Male SD rats were randomly divided into sham-operated group, untreated group, captopril treated group and losartan-treated group. The animal models were produced by permanent occlusion of bilateral common carotid arteries by operation for two times at 3 days interval. The ability of learning and memory of the rats were tested by Morris water maze. Results The average escape latency in vascular dementia rats treated with captopril and losartan was significantly shorter than that in untreated rats （P 〈 0.05）. Conclusion captopril and losartan can improve the ability of learning and memory of the rats with vascular dementia.