摘要
阿尔茨海默病是一种以进行性认知障碍和记忆力损害为主的中枢神经系统退行性疾病。目前普遍认为，发病关键环节之一是β淀粉样蛋白在脑部神经元的异常积聚，形成“老年斑块”和“神经元纤维缠结”。近年的调查研究及系列关联分析显示，SORL1（the neuronal sortilin-related receptor，SORLA、LR11）基因能够明显增加阿尔茨海默病的患病风险，共机制与SORL1蛋白调控β淀粉样蛋白的相关代谢途径有关。现就近年来两者间的相关性研究进展作一综述。
出处
《中华老年心脑血管病杂志》
CAS
北大核心
2010年第6期571-573,共3页
Chinese Journal of Geriatric Heart,Brain and Vessel Diseases
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