肺血栓栓塞症应用溶栓与抗凝治疗的疗效比较

Comparison of Efficacy of Thrombolytic Therapy versus Anticoagulant Therapy in Treatment of Pulmonary Thromboembolism

目的比较尿激酶溶栓方案和低分子肝素抗凝方案治疗肺栓塞的临床疗效。方法对48例PE患者的临床资料进行回顾性分析。结果溶栓组和抗凝组治疗后心率、呼吸频率均明显减慢,动脉血氧分压(PaO2)、动脉血二氧化碳分压(PaCO2)也均明显改善,但抗凝组不如溶栓组显著(P<0.05)。溶栓组和抗凝组总有效率分别为96.2%、88.5%,两组总有效率比较,差异有显著性(P<0.05)。结论尿激酶溶栓治疗疗效优于低分子肝素抗凝治疗。

Objective To compare the clinical efficacy of thrombolytic therapy with Urokinase versus anticoagulant therapy with low-molecular-heparin in the treatment of pulmonary embolism（PE）.Methods Clinical data of 48 patients with PE were retrospectively analyzed.Results Heart rate and breathing rate of the thrombolysis group and anticoagulation group decreased significantly after therapy.PaO2 and PaCO2 decreased significantly as well,but the anticoagulation group was less marked than the thrombolysis group（P0.05）.The total effective rates of the thrombolysis group and anticoagulation group were respectively 96.2% and 88.5%,total effectiveness of the two groups compared,having a significant difference（P0.05）.Conclusion The therapeutic efficacy of thrombolytic therapy with Urokinase is higher than that of anticoagulant therapy with low-molecular-heparin in the treatment of pulmonary embolism.