多潘立酮联合帕罗西汀治疗功能性消化不良50例临床分析

Clinical Analysis of Patients with Functional Dyspepsia Treated by Domperidone and Paroxetine

目的:探讨多潘立酮联合帕罗西汀治疗功能性消化不良的临床疗效。方法:将2007年1月至2009年10月在我院消化门诊就诊的100例功能性消化不良患者随机分为对照组和治疗组各50例,对照组应用多潘立酮治疗,治疗组在对照组治疗的基础上联合帕罗西汀治疗;两组疗程均为4周。结果:治疗组总有效率88%显著高于对照组的70%(P<0.05),两组均无明显不良反应。结论:多潘立酮联合帕罗西汀治疗功能性消化不良疗效满意,且使用方便、安全。

Objective：To explore the clinical efficacy of patients with functional dyspepsia treated by Domperidone and Paroxetine. Methods： 100 patients with functional dyspepsia were divided into control group and treatment group randomly from Jan 2007 to Oct 2009, and each group was 50 cases. The control group was treated by Domperidone, while the treatment group was treated by Domperidone and Paroxetine for 4 weeks. Results： The total effective rate in treatment group and the control group were 88% and 70%. There was significant difference between the two groups （P〈0.05）. There was no obvious side effect in both groups. Conclusion： Combining Domperidone and Paroxetine is an effective, convenient and safe method to functional dyspepsia.