多囊卵巢综合征诱发排卵转体外受精-胚胎移植效果分析

Analysis of Effect of in Vitro Fertilization and Embryo Transfer to Patients with Polycystic Ovarian Syndrome in Stimulating Ovulation

目的探讨多囊卵巢综合征(PCOS)促排卵时多个卵泡发育改做体外受精-胚胎移植(IVF-ET)的效果。方法对PCOS合并不孕的患者进行促排卵,如果发育卵泡≥7个者建议改行IVF-ET,设为研究组,PCOS患者常规进行IVF-ET的作为对照组,比较两组临床结果。结果研究组促性腺激素用量明显少于对照组(14.74±6.76 vs 22.41±7.55)支,P<0.05,妊娠率略高于对照组(70.6%vs 48.4%),两组取卵数、受精率、移植胚胎数、多胎率、卵巢过度刺激综合征(OHSS)发生率、流产率无明显差异。结论 PCOS患者诱发排卵卵泡发育过多时改行穿刺取卵体外受精可有效降低OHSS和多胎率,是一种经济有效的治疗方法 。

Objective To study the effects of in vitro fertilization and embryo transfer（IVF-ET） on infertility patients with PCOS in stimulating ovulation with multiple follicules growing.Methods Giving human menopause gonadotropin to infertility patients with PCOS,we chosed IVF-ET to treat the infertility if there were more than 7 follicules to grow.These patients were set to study group.The control group was PCOS patients treated by traditional IVF-ET.The clinical effects of two groups were compaired.Results In study group,the number of gonadotrophin（Gn） was significantly fewer than that in control group（14.74±6.76 vs 22.41±7.55） amples,P0.05.The pregnancy rate of study group was little higher than the control＇s（70.6% vs 48.4%）.There were no difference in the numbers of oocyte retrieved and embryo transfered.The fertilization rate and ovarian hyperstimulation syndrome（OHSS） rate and multiple pregnancy rate were similar between two groups.Conclusion The IVF-ET could effectly reduce the OHSS rate and multiple pregnancy rate if there were more follicles growing in stimulating ovulation to PCOS.IVF-ET was an economical and effective method to treat infertility of PCOS.