鹿茸胶原酶解物抗炎免疫抗应激作用的实验研究

On anti-inflammation,immune regulation and anti-stress effect of cartialgenous collagen zymolyte

目的:观察鹿茸胶原酶解物的抗炎、免疫及抗应激作用。方法:通过小鼠足肿胀的实验观察鹿茸胶原酶解物的抗炎作用;通过观察2,4二硝基氯苯(DNCB)致小鼠的迟发型超敏反应(DTH)和网状内皮系统吞噬功能的影响观察鹿茸胶原酶解物的免疫调节作用;通过观察小鼠耐缺氧和耐疲劳实验观察鹿茸胶原酶解物对小鼠的应激反应影响。结果:鹿茸胶原酶解物对角叉菜胶引起的足肿胀有抑制作用;能抑制二硝基氯苯所致小鼠迟发型超敏反应和提高小鼠巨噬细胞吞噬功能;具有抗应激作用,可增强小鼠机体抗疲劳的非特异性抵抗力。结论:鹿茸胶原酶解物具有明显的抗炎、免疫调节、抗应激作用。

Objective：To investigate the anti-inflammation,immune regulation and anti-stress effect of cartialgenous collagen zymolyte.Methods：The anti-inflammatory effect was observed by carrageenan-induced foot swelling test,the immune effect was observed by delayed-type hypersensitivity （DTH） induced by 2,4-dinitrochlorobenzene and the anti-stress effect was observed by hypoxia tolerance and fatigue tolerance. Results：The cartialgenous collagen zymolyte can inhibit the carrageenan-induced foot swelling and delayed-type hypersensitivity （DTH） induced by 2,4-dinitrochlorobenzene,and improve the macrophagocyte phagocytosis function,and enhance the body,s non-specific resistance to fatigue.Conclusion：Cartialgenous collagen zymolyte appeared obvious immune regulation,anti-inflammation and anti-stress effect.