摘要
目的：研究氯化铝（AlCl3）染毒对大鼠心脏的毒性及铝螫合剂1，2-二甲基-3-羟基-4-吡啶酮（去铁酮）的保护作用。方法：35只雄性Wistar大鼠，按体质量随机分为阴性对照组、铝染毒组及去铁酮低、中、高剂量组。前8周阴性对照组给予生理盐水，其余各组给予AlCl3172．5mg／（kg·d），每周5次，后2周，去铁酮低、中、高剂量组分别给予不同剂量的去铁酮，其余组给予生理盐水。测定心肌组织中铝、锌、铜、铁、钙、镁的含量。结果：心肌铁含量低于阴性对照组（P〈0．05=；心肌铜、锌、钙、镁的含量在各组间比较差异无统计学意义。结论：AlC3可致大鼠心肌损伤，铝螯合剂去铁酮在排铝的同时，不影响心肌中必需元素的含量，改善砧C3所致的心肌损伤。
Objective：To explore the cardiac toxicity in rats exposed to aluminum chloride （AlCl3） ,and the inhibition of 1,2-dimethyl-3-hydrxy-4-pyridone （deferiprone） .Methods：35 male Wistar rats were seperated to 5 groups randomly by weight. The four groups except the negative control group were adminstered akuminum chloride （172.5mg/（kg · d）） for 8 weeks, then the different doses of deferiprone were given to the lower, median, higher groups.the rest were given the NS. The contents of aluminum and the essential elements were determined^-1 Results：The content of Fe in cardiac muscle of the Al group is significantly lower than the negative group （P〈0.05） ; while there is no significant difference between groups of Zn,Mg,Cu,Ca in the cardiac muscke. Conclusion;deferiprone is effective tor aluminum elimination,and no effective to other essential elments.
