摘要
目的:观察外用0.05%视黄醛联合0.5%及1%透明质酸片段对中国人面部皮肤抗老化的功效性和安全性。方法:采用多中心研究,将受试者分为3组,分别于整个面部使用含0.05%视黄醛+0.5%透明质酸片段制剂;于深皱纹区域使用含0.05%视黄醛+1%透明质酸片段制剂及两种制剂联合应用。经90 d观察期,评估包括照片分级评分、面部肤色均匀度、皮肤干燥度、色素沉着、皮肤弹性及局部皱纹程度等多项老化指标,对2种外用制剂进行耐受性评估。结果:3组老化指标均有改善。照片分级评分降低,面部肤色均匀度改善,皮肤干燥度、色素沉着、皮肤弹性等皮肤老化体征均有改善。除1组受试者眉间纹外局部深皱纹程度均有改善。不良反应轻微。结论:视黄醛联合透明质酸片段外用可改善多种皮肤老化征象,安全有效。
Objective:To investigate the anti-aging efficacy and safety of topical preparations containing 0.05% retinaldehyde and 0.5% or 1% hyaluronate fragments. Methods:Subjects were divided into 3 groups in this open design multicentre study, group 1 was applied with 0.05% retinaldehyde and 0.5% hyaluronate fragments on the whole face, group 2 with 0.05% retinaldehyde and 1% hyaluronate fragments on the areas presenting deep wrinkles, group 3 with the both. The photographic scale of facial photo-aging, skin color homogeneity, dryness, hyperpigmentation, skin elasticity were evaluated after 90 days and the toleration of the preparations assessed. Results:All the groups had improvements. The photographic scale of facial photo-aging decreased, and skin color homogeneity, dryness, hyperpigmentation, skin elasticity were improved. For each treatment group, the wrinkles except the glabella of group 1 released with mild adverse effect. Conclusion:Topical preparations containing retinaldehyde and hyaluronate fragments can improve skin aging with efficacy and safety.
出处
《临床皮肤科杂志》
CAS
CSCD
北大核心
2010年第7期420-422,共3页
Journal of Clinical Dermatology
关键词
视黄醛
透明质酸片段
抗老化
功效
安全性
retinaldehyde
hyaluronate fragments
anti-aging
efficacy
safety